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Article

The causal effect of family history of cardiovascular disease on erectile dysfunction: a randomized clinical study and Mendelian randomization study.

Asian journal of andrology - 1 Sept 2026

Li Dong-Jie, Xiang Bo-Yu, Li Yong, Zhang Chi-Teng, Liu Li, Li Xiu-Cheng

Abstract excerpt

Erectile dysfunction (ED) is increasingly recognized as an early clinical marker of cardiovascular disease (CVD); however, the causal role of familial predisposition to CVD in ED development remains insufficiently defined. This study investigated whether genetic susceptibility associated with a parental history of CVD exerts a causal influence on ED risk, integrating clinical data with Mendelian randomization...

Read the complete abstract on PubMed

Topics

Humans
Male
Cardiovascular Diseases
Mendelian Randomization Analysis
Erectile Dysfunction
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genome-Wide Association Study

Adult

Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 41873544
DOI: 10.4103/aja202584
PMCID: PMC13623309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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