X-linked adrenoleukodystrophy as an etiological cause of progressive spastic paraplegia: A case report.

Abstract excerpt

X-linked adrenoleukodystrophy is a rare peroxisomal disorder caused by mutations in ABCD1, thereby resulting in impaired β-oxidation of very long-chain fatty acids. Its adult-onset form, adrenomyeloneuropathy, typically presents as progressive spastic paraparesis that mimics hereditary spastic paraplegia. Brain and spinal magnetic resonance imaging findings are often unremarkable, contributing to diagnostic...

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• Adrenoleukodystrophy
• ATP Binding Cassette Transporter, Subfamily D, Member 1
• Fatty Acids
• ABCD1 gene
• Magnetic Resonance Imaging