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Adaptive VP1 sites 93 and 97 modulate antigenic evolution and receptor binding of Senecavirus A: Phylogenetic analysis and validation with recombinant viruses.

Veterinary microbiology - 1 May 2026

Yang Jing, Zhang Zhiliang, Sha Weijia, Peng Mingyue, Li Yize, Ge Xiaoyu, Li Jiaxuan, Cui Wen, Jiang Yanping, Wang Xiaona, Tang Lijie

Abstract excerpt

Since 2014, Senecavirus A (SVA) has caused recurrent vesicular disease outbreaks in pigs and continues to circulate widely. However, functional evidence is limited as to whether mutations accumulated during long-distance spread alter receptor engagement or antigenicity, constraining sequence-based risk prioritization. We analyzed 263 quality-controlled, coding-complete SVA genomes after removing recombinant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41865606
DOI: 10.1016/j.vetmic.2026.110997

Genes

ANTXR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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