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Exometabolome variation in the fungal pathogen of humans Candida albicans reveals specificities at the genetic clade and strain levels.

Applied and environmental microbiology - 22 Apr 2026

Alaban Leovigildo Rey, Bunescu Andrei, Abi-Ghanem Joséphine, Bequet Frédéric, Lebrat Julien, Tulinski Pawel, Kosmala Daria, Bougnoux Marie-Elisabeth, d'Enfert Christophe, Thomas Vincent

Abstract excerpt

Candida albicans is a fungal pathobiont that thrives in different host niches and successfully confronts the host immune defenses. The success of C. albicans as a pathogen relies on a highly plastic metabolism, with examples of variations across isolates; however, detailed characterization of how C. albicans genetic diversity impacts the content of the metabolome is still missing. Here, we have implemented an NMR...

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PMID: 41848408
DOI: 10.1128/aem.01512-25
PMCID: PMC13101467

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