Polymorphisms in IRF3 exon 1 influence the immune response to Brucella infection in small ruminants.

doi:10.1007/s00335-026-10212-9

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Article

Polymorphisms in IRF3 exon 1 influence the immune response to Brucella infection in small ruminants.

Mammalian genome : official journal of the International Mammalian Genome Society - 14 Mar 2026

Rossi U A, Caffaro M E, Gaute D N, Castaño M R, Maurizio E, Poli M A, Rossetti C A

Abstract excerpt

Brucellosis in small ruminants is primarily caused by Brucella ovis and zoonotic B. melitensis. IRF3 is a key transcription factor for IFNα/β gene induction in response to intracellular pathogens. Previously, we identified a genetic association between the rs540 deletion (a-allele) in IRF3 exon 1 and an increased resistance to B. melitensis natural infection in goats. Here, we studied the effect of IRF3 exon 1...

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PMID: 41832384
DOI: 10.1007/s00335-026-10212-9

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