Subchronic, low-frequency polystyrene microplastic or nanoplastic exposure elicits molecular perturbations but minimal clinical phenotypes in the mouse gut-brain axis.

Abstract excerpt

The global public concerns about micro- and nanoplastics (MNPs) are on the rise, whereas the mechanisms underlying MNP-mediated toxicity have not been fully elucidated. In particular, toxic responses in the gut-brain axis of mice varied across studies due to the high variability in experimental exposure designs. Thus, we employed a mouse model (n = 46) with a standardized exposure regimen of 0.3 mg per treatment,...

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