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Establishment and Evaluation of Human iPS Cell-Derived Myeloid Cell Lines Susceptible to SARS-CoV-2.

Microbiology and immunology - 1 May 2026

Hishiki Takayuki, Yoshimura Yuka, Suzuki Rieko, Murakami Ami, Saito Yua, Tanga Naomi, Shimizu Jun, Watashi Koichi, Takasaki Tomohiko, Miyazaki Kazuo

Abstract excerpt

To accelerate the development of antiviral drugs, we generated human iPS cell-derived myeloid cell lines, which were susceptible to SARS-CoV-2 infection. Viral isolation using clinical specimens showed that some novel cell lines performed better than VeroE6/TMPRSS2. In addition, viral genome mutations that occurred during viral passaging did not happen in VeroE6/TMPRSS2 but accumulated in these cell lines, and...

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Adenosine Monophosphate
Alanine
Chlorocebus aethiops
COVID-19
Induced Pluripotent Stem Cells

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PMID: 41806175
DOI: 10.1111/1348-0421.70053

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TMPRSS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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