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Article

Association of C5AR1 polymorphisms with increased gastric cancer risk: mechanistic insights and therapeutic implications targeting JAK/STAT pathway.

Gene - 15 May 2026

Wang Zhongqi, Jian Ying, Jiang Xiaomei, Zhang Hongmei, Zhang Zhi, Zhang Xuemei

Abstract excerpt

While the pivotal role of C5a receptor 1 (C5AR1) in cancer immunity is well-established, its specific genetic and functional contributions to gastric cancer (GC) remain elucidated. This study investigates the correlation between C5AR1 polymorphisms with GC risk, alongside exploring the underlying molecular mechanisms. Genotyping was conducted utilizing a PCR-based method for identifying restriction fragment...

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Source

Identifiers

PMID: 41794198
DOI: 10.1016/j.gene.2026.150086

Genes

C5AR1
GC
CCK
JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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