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Article

Dual membrane-spanning anti-sigma 2 controls OMV biogenesis and colonization fitness in Bacteroides thetaiotaomicron.

Journal of bacteriology - 23 Apr 2026

Pardue Evan J, Zhong Tengfei, Scott Nichollas E, Jana Biswanath, Beatty Wandy, Ortiz-Marquez Juan C, Kaplan Mohammed, Jackson-Litteken Clay, Feldman Mario F

Abstract excerpt

Bacteroides spp. are gram-negative, gut commensals that shape the enteric landscape by producing outer membrane vesicles (OMVs) that degrade dietary fibers and traffic immunomodulatory biomolecules. Understanding the mechanism behind OMV biogenesis in Bacteroides spp. is necessary to determine their role in the gut. Recent studies showed that mutation of dual membrane-spanning anti-sigma factor 1 (Dma1) increased...

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Identifiers

PMID: 41784630
DOI: 10.1128/jb.00442-25
PMCID: PMC13088901

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