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Article

Cost-effectiveness of primary HPV genotyping and dual-stain or cytology reflex testing versus cytology-based screening for cervical cancer in Chile.

PloS one - 1 Jan 2026

Armijo Nicolas, Espinoza Manuel A, Contreras-Montiel Pilar, Vera Macarena, Balmaceda Carlos

Abstract excerpt

Testing for high-risk human papillomavirus with genotyping for types 16 and 18 (HPV16/18) and triage by p16/Ki-67 dual-stain immunocytochemistry improves diagnostic performance in cervical cancer screening. We estimated the cost-effectiveness of HPV DNA-based primary screening strategies that detect high-risk genotypes every 5 years with either reflex cytology (hrHPV-Pap-5) or reflex dual stain (CINtec® PLUS,...

Topics

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Chile
Cost-Benefit Analysis
Early Detection of Cancer
Genotype
Human papillomavirus 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Human papillomavirus 18

Papillomavirus Infections

Uterine Cervical Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 41779704
DOI: 10.1371/journal.pone.0332010
PMCID: PMC12959674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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