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Article

Management and Consequences of Genotype-Positive Familial Hypercholesterolemia.

JAMA cardiology - 1 Apr 2026

Spinks Catherine, Selvaraj Margaret Sunitha, Robinson Christopher, Peloso Gina M, Gwynne Courtney, Urbut Sarah, Truong Buu, Paruchuri Kaavya, Hornsby Whitney, Natarajan Pradeep

Abstract excerpt

Importance: Familial hypercholesterolemia (FH) is a common genetic condition that causes hypercholesterolemia and increased risk for premature atherosclerotic cardiovascular disease (ASCVD). The prevalence, management, and consequences of genetically confirmed FH across the US are poorly understood. Objective: To identify genotype-positive FH in a national US cohort and describe its prevalence, consequences, and...

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Share to Anticholesteremic Agents
Share to Apolipoprotein B-100

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hyperlipoproteinemia Type II

Share to Proprotein Convertase 9

Share to Receptors, LDL

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Source

Open in PubMed Open full text

Identifiers

PMID: 41779414
DOI: 10.1001/jamacardio.2026.0006
PMCID: PMC12961599

Genes

FH
APOB
LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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