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Article

Pathophysiology of androgen-associated endothelial cell dysfunction in phenotype A polycystic ovarian syndrome revealed by iPSCs modeling.

Frontiers in endocrinology - 1 Jan 2026

Wu Chia-Eng, Huang Chu-Chun, Hsiao Yung-Jen, Hsu Chia-Lang, Chen Tzu-Hsin, Chen Mei-Jou, Ho Hong-Nerng

Abstract excerpt

Introduction: Abundant evidence suggests that women with polycystic ovary syndrome (PCOS) have increased metabolic aberrations and cardiovascular risks and present with signs of endothelial cell (EC) dysfunction. However, whether and how androgen is involved in the pathogenesis of EC dysfunction in PCOS remains unclear. Methods: In this study, induced pluripotent stem cells (iPSCs) were established from three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41767389
DOI: 10.3389/fendo.2026.1682793
PMCID: PMC12935609

Genes

AR
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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