Article
Detection of human papillomavirus (HPV)-specific T cell response in women with low-grade cervical intraepithelial lesion and HPV vaccinated subjects.
Frontiers in immunology - 1 Jan 2025
Zelini Paola, Zavaglio Federica, Dominoni Mattia, Valsecchi Marta, Lo Grasso Lucrezia, d'Angelo Piera, Giardina Federica, Romano Greta, Paolucci Stefania, Lilleri Daniele, Cassaniti Irene, Spinillo Arsenio, Baldanti Fausto, Gardella Barbara
Abstract excerpt
Background: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and HPV-driven cervical cancers remain a major health concern. This study aimed primarily to develop a test for assessing and characterizing HPV-specific T-cell responses, in HPV-vaccinated women and women with cervical intraepithelial neoplasia (CIN)1. Methods: T-cell responses against HPV-16 and 18 L1, E6, and E7...
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