A case of anti-Rh17 (anti-Hro) antibody in D··phenotype, a rare alloimmunization complicating transfusion management.

doi:10.1016/j.transci.2026.104410

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Article

A case of anti-Rh17 (anti-Hro) antibody in D··phenotype, a rare alloimmunization complicating transfusion management.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis - 1 Jun 2026

Augustine Merline, Parulekar Aditi, Amoncar Sangeeta, Mallya M V

Abstract excerpt

Rh blood group system is highly immunogenic, encoded by two closely linked genes; RHD and RHCE. The proximity of the genes can result in mutations resulting in hybrid genes and hence Rh variants like D-- and D··. Both variants are similar, difficult to distinguish serologically. D·· is characterized by RH CE-D-CE rearrangement resulting in Evans antigen. Anti-Rh17/Hro formed as a result of alloimmunization can...

Topics

Humans
Female
Middle Aged
Rh-Hr Blood-Group System
Blood Transfusion
Isoantibodies
Phenotype

Source

Open in PubMed

Identifiers

PMID: 41762820
DOI: 10.1016/j.transci.2026.104410

Genes

RHCE
RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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