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Genome-Wide Association Reveals Signalling-Linked Infection Tolerance in Hibernating Bats.

Pathogens (Basel, Switzerland) - 30 Jan 2026

Harazim Markéta, Piálek Lubomír, Bandouchova Hana, Pikula Jiri, Seidlová Veronika, Zukal Jan, Němcová Monika, Heger Tomas, Linhart Petr, Piaček Vladimír, Kokurewicz Tomasz, Orlov Oleg L, Zahradníková Alexandra, Martínková Natália

Abstract excerpt

Hibernation profoundly alters host-pathogen dynamics by suppressing metabolism and immune function, posing unique challenges for infection control. In this study, we examined how genomic variation modulates infection and physiological traits in temperate bats during hibernation. We combined infection screening, haematology, blood biochemistry, and whole-genome sequencing across five vespertilionid species,...

Topics

Animals
Chiroptera
Hibernation
Genome-Wide Association Study
Signal Transduction
Polymorphism, Single Nucleotide
Host-Pathogen Interactions
Immune Tolerance

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PMID: 41754402
DOI: 10.3390/pathogens15020149
PMCID: PMC12943343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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