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Novel CRISPR/Cas9-Derived mlo Alleles in Barley: Resistance to Powdery Mildew and Microbiome Implications.

International journal of molecular sciences - 14 Feb 2026

Eskildsen Jovana, Dong Menghui, Hanak Tobias, Madsen Claus Krogh, Holme Inger, Plaszkó Tamás, Vestergård Mette, Nicolaisen Mogens, Thordal-Christensen Hans, Brinch-Pedersen Henrik

Abstract excerpt

Barley grown in temperate regions is often challenged by powdery mildew disease. An effective solution is mildew resistance locus o (mlo)-based resistance, which is monogenic, durable, and broad-spectrum. While the pleiotropic effects of mlo mutations on above-ground tissues are well documented, their impact on the root-associated microbiome remains underexplored. We utilized CRISPR/Cas9 to generate novel mlo...

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PMID: 41751979
DOI: 10.3390/ijms27041846
PMCID: PMC12941145

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