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Article

A standardized microinjection framework with hierarchical quantitative evaluation supports multi-genotype human norovirus replication modeling in zebrafish embryos.

Journal of applied microbiology - 5 Mar 2026

Ouyang Ziwang, Chen Yiqing, Xu Ruiquan, Wang Jingmin, Gao Junshan, Ding Yanyan, Xue Liang, Kou Xiaoxia

Abstract excerpt

AIMS: To establish a reproducible and consistent zebrafish embryo model for multi-genotype human norovirus (HuNoV) replication, by addressing the critical bottleneck of technical variability in microinjection and systematically characterizing the infection dynamics across genotypes. METHODS AND RESULTS: We developed a standardized microinjection framework anchored by a hierarchical quantitative evaluation scheme...

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Identifiers

PMID: 41746269
DOI: 10.1093/jambio/lxag039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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