A robust human norovirus replication model in zebrafish larvae

Abstract excerpt

Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year.The lack of robust small animal models has significantly hindered the understanding of norovirus biology and the development of effective therapeutics.Here we report that HuNoV GI and GII replicate to high titers in zebrafish (Danio rerio) larvae; replication peaks at day 2 post...

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