RGTFormer: Predicting mutation-associated multi-drug resistance in Mycobacterium tuberculosis using a categorical gated transformer and relational graph convolutional network.

Abstract excerpt

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health concern, especially due to multi-drug resistance. Resistance often arises from single nucleotide mutations in drug-target genes, making early prediction vital for effective treatment. Genomic sequencing enables resistance profiling, but accurate prediction requires advanced computational models. This study presents RGTFormer, a...

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