Wilson's disease: does a neuropsychiatric phenotype without liver involvement truly exist?

Abstract excerpt

INTRODUCTION: Wilson’s disease (WD) is an inherited disorder of copper metabolism resulting in pathological copper accumulation in multiple organs, predominantly the liver, kidneys, and brain, with subsequent organ damage due to copper toxicity. Although the underlying metabolic defect originates in impaired hepatic copper transport with early hepatocellular injury, the currently accepted clinical phenotypic...

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