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Article

Failure of podocalyxin suppression and HOXA10/HOXA11 activation characterizes endometrial dysfunction in hyperandrogenic PCOS.

Molecular and cellular endocrinology - 1 Jun 2026

Celik Nilufer, Celik Onder, Ulug Ulun, Ersahin Aynur, Gurkan Naziye, Gungor Kagan, Yardim Meltem, Dalkilic Semih, Tektemur Ahmet, Celik Sudenaz, Gungor Nur Dokuzeylul, Duran Cevdet

Abstract excerpt

To analyze the effects of hyperandrogenemia (HA) in polycystic ovary syndrome (PCOS) on negative and positive regulators of endometrial receptivity. Fifty-four women with PCOS undergoing total embryo freezing were classified into four phenotypes: classical type A, classical type B, ovulatory type C, and normoandrogenic type D. Hyperandrogenemia was present in phenotypes A-C and absent in phenotype D. Twenty-five...

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Case-Control Studies
Endometrium
Homeodomain Proteins
Hyperandrogenism
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Ovary Syndrome

Sialoglycoproteins

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Identifiers

PMID: 41713640
DOI: 10.1016/j.mce.2026.112763

Genes

HOXA10
HOXA11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Failure of podocalyxin suppression and HOXA10/HOXA11 activation characterizes endometrial dysfunction in hyperandrogenic PCOS.PMID 41713640Read ↗

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