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Article

Uncovering genetic variation in humoral inborn errors of immunity in African populations: insights from the African genome variation database.

Scientific reports - 15 Feb 2026

Hlongwa Luyanda, Meintjes Ayton, Mulder Nicola, Mayne Elizabeth

Abstract excerpt

Inborn Errors of Immunity (IEIs) are rare genetic disorders affecting immune function. Humoral IEIs, the most commonly diagnosed subtype, are characterised by antibody deficiencies. There is limited data regarding the variation of genes associated with humoral IEI in Africa with implications for designing genetic assays for testing for these diseases. This study aimed to assess the genetic variation in genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Source

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Identifiers

PMID: 41692833
DOI: 10.1038/s41598-026-39612-2
PMCID: PMC12996604

Genes

CR2
RAG1
TCF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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