Article
Anti-Ku alloimmunization due to a KEL*02N.19 allele causing Kell-null phenotype despite KEL*02 genotype prediction.
Vox sanguinis - 1 May 2026
Dara Ravi C, Madkour Rania, Bensing Kathleen, Alzaabi Eiman, Sadiq Ihsanullah, Chada Nyaradzo, Mawad Ghada H, Puca Kathleen E, Algora Manuel
Abstract excerpt
BACKGROUND AND OBJECTIVES: Alloantibodies against high-prevalence antigens can create significant barriers to transfusion, particularly in patients with complex medical needs. Serological investigations include use of enzyme-treated red cells and dithiothreitol (DTT) testing, which can enhance or diminish antibody reactivity, providing insight into potential antibody specificity. Additionally, molecular testing...
Topics
- Humans
- Female
- Kell Blood-Group System
- Isoantibodies
- Alleles
- Genotype
- Ku Autoantigen
- Phenotype
- Erythrocyte Transfusion
- Membrane Glycoproteins
- Metalloendopeptidases
