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Tetrapyrrole biosynthetic intermediates act as chloroplast-to-nucleus retrograde signals to regulate intercellular trafficking via plasmodesmata.

The New phytologist - 1 Apr 2026

Azim Mohammad F, Gifford Levi B, Alazem Mazen, Woodson Jesse D, Burch-Smith Tessa M

Abstract excerpt

Intercellular communication via plasmodesmata (PD) is essential for plant growth, development, and defense, yet its regulation remains poorly understood. We set out to identify the chloroplast retrograde signals that regulate intercellular trafficking via PD. Using a combination of Arabidopsis thaliana mutants and gene silencing in Nicotiana benthamiana, we found that the metabolites of the tetrapyrrole...

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PMID: 41656792
DOI: 10.1111/nph.70978

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