Comparative whole-genome sequencing of seven invasive Streptococcus pneumoniae isolates from Malaysia reveals genetic diversity, recombination events, and global lineage linkages.

Abstract excerpt

BACKGROUND: Streptococcus pneumoniae remains a major global health threat, causing diseases ranging from mild respiratory infections to severe conditions like pneumonia, sepsis, and meningitis. Although pneumococcal conjugate vaccines (PCVs), including PCV7, PCV10, and PCV13 have significantly reduced disease burden, especially in children, S. pneumoniae continues to exhibit high serotype and genetic diversity....

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