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Genetic and epidemiological patterns of primary immunodeficiency diseases in Eastern Iranian patients.

Scientific reports - 2 Feb 2026

Salehi Mohammad, Ahanchian Hamid, Karimiani Ehsan Ghayoor, Aelami Mohammad Hassan, Moazzen Nasrin, Neshati Zeinab, Pasdar Alireza

Abstract excerpt

Primary immunodeficiency diseases (PIDs) are monogenic inborn immune disorders. Of currently listed 555 genetic inborn errors of immunity (IEI) in 10 IUIS categories, PIDs range from life-threatening severe combined immunodeficiency (SCID) to milder antibody deficiencies. PIDs increase mortality risk and demand genetic/immunological testing. In Iran, high consanguinity rates may warrant influence of genetic...

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PMID: 41629504
DOI: 10.1038/s41598-026-35604-4
PMCID: PMC12921212

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