Article
Resequencing and De Novo Assembly of Leishmania (Viannia) guyanensis from Amazon Region: Genome Assessment, Phylogenetic Insights and Therapeutic Targets.
Pathogens (Basel, Switzerland) - 22 Jan 2026
Costa Lucas George Assunção, Sousa Junior Edivaldo Costa, Cardoso Camila Cristina, Igreja Millena Arnaud Franco da, Acosta Franklyn Samudio, Silva Fabiano Reis da, Garcez Lourdes Maria
Abstract excerpt
Leishmania guyanensis is one of 15 American human-pathogenic species, frequently linked to therapeutic failure due to its marked genetic plasticity and adaptability under drug pressure. To broaden the genomic understanding of this species, its biological traits, and potential therapeutic alternatives, we sequenced the L. guyanensis strain MHOM/BR/75/M4147. Raw reads underwent quality-filtering and assembly....
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