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Structural Mapping of Surveillance Data Reveals Conservation of NNI Binding Site in RSV L Protein.

Pathogens (Basel, Switzerland) - 13 Jan 2026

Patel Ruchin, Murray Edward, Nahas Debbie D, Yazdani Mahdieh, Ambler Brett, Murgolo Nicholas, Howe John A

Abstract excerpt

Respiratory syncytial virus (RSV) remains a leading cause of lower respiratory tract infections (LRTIs) and infant mortality worldwide. Despite recent advances in prophylactic interventions, effective therapeutics for active RSV infection are still lacking. Small molecule non-nucleoside inhibitors (NNIs) targeting the RSV L protein, particularly its polyribonucleotidyltransferase (PRNTase) domain, represent a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41599069
DOI: 10.3390/pathogens15010085
PMCID: PMC12844714

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