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Genetic, Epigenetic, and Non-Genetic Factors in Testicular Dysgenesis Syndrome: A Narrative Review.

Genes - 31 Dec 2025

Ciarloni Alessandro, Delli Muti Nicola, Sacco Sara, Ambo Nicola, Di Giacomi Valentina, Perrone Michele, Rossi Silvia, Balercia Marinella, Salvio Gianmaria, Balercia Giancarlo

Abstract excerpt

BACKGROUND: Testicular dysgenesis syndrome (TDS) is a complex disorder of the male reproductive system related to disfunction of the fetal testis. The clinical features of TDS may be evident at birth or infancy (cryptorchidism, hypospadias and/or reduced anogenital distance) or occur later in adulthood (testis cancer, infertility). Genetic background seems to be important for genetic predisposition, with new...

Topics

Humans
Male
Gonadal Dysgenesis
Epigenesis, Genetic
Genetic Predisposition to Disease
Testis
Cryptorchidism
Female

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41595460
DOI: 10.3390/genes17010040
PMCID: PMC12841294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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