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Article

Phenotypic impact on coat color and uterine development in mice carrying a missense mutation associated with bovine White Heifer Disease.

The Journal of veterinary medical science - 2 Apr 2026

Wu Yinga, Sekiguchi Marie, Nakadaira Yoko, Ishiyama Dai, Magata Fumie, Fujii Wataru, Kyuwa Shigeru, Matsuda Fuko, Kakuta Shigeru

Abstract excerpt

White Heifer Disease (WHD) is a congenital reproductive abnormality, especially in white female offspring in certain breeds of cattle like Belgian Blue. The roan locus was reported to affect coat color and fertility. It was suggested that a missense mutation (Ala218Asp) in the transmembrane domain of Kit ligand (KITL) gene was responsible for WHD. Here we generated two types of knock-in (KI) mice to reproduce the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41581903
DOI: 10.1292/jvms.25-0542
PMCID: PMC13062579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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