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Article

In steroid-resistant nephrotic syndrome that meets the strict definition, monogenic variants are less common than expected.

Pediatric nephrology (Berlin, Germany) - 1 Dec 2024

Ichikawa Yuta, Sakakibara Nana, Nagano China, Inoki Yuta, Tanaka Yu, Ueda Chika, Kitakado Hideaki, Kondo Atsushi, Ishimori Shingo, Horinouchi Tomoko, Iijima Kazumoto, Nozu Kandai

Abstract excerpt

BACKGROUND: In patients with steroid-resistant nephrotic syndrome (SRNS), the presence of monogenic variants influences therapeutic strategies. Large cohort studies reported the detection of monogenic variants in approximately 30% of patients with SRNS. However, these cohorts included many patients, such as those with symptomatic proteinuria, who did not meet the strict diagnostic criteria for pediatric nephrotic...

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Identifiers

PMID: 39093455
DOI: 10.1007/s00467-024-06468-5
PMCID: PMC11511720

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