Association of NXP2 autoantibodies with a more severe clinical phenotype of juvenile dermatomyositis.

doi:10.55563/clinexprheumatol/820f4x

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Article

Association of NXP2 autoantibodies with a more severe clinical phenotype of juvenile dermatomyositis.

Clinical and experimental rheumatology - 1 Feb 2026

Wang Yini, Liang Junyu, Wang Jia, Zheng Fei, Teng Liping, Ma Qian, Zhou Yun, Liang Lingfang, Lin Jin, Lu Meiping, Cao Heng, Xu Xuefeng

Abstract excerpt

OBJECTIVES: Myositis specific autoantibodies (MSAs) correlate with a distinct clinical phenotype of juvenile dermatomyositis (JDM). This study aims to compare the clinical features of JDM patients with positive anti-NXP2, anti-MDA5 and anti-TIF1γ autoantibodies, and differences in juvenile (JDM) and adult dermatomyositis. METHODS: This study included 18 NXP2+ JDM patients, 12 MDA5+ JDM patients, 12 TIF1γ+ JDM...

Topics

Humans
Dermatomyositis
Autoantibodies
Female
Phenotype
Interferon-Induced Helicase, IFIH1
Child
Male
Severity of Illness Index
Adolescent
Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Creatine Kinase

Adult

Recurrence

Young Adult

Interleukin-10

Interferon-gamma

Child, Preschool

Source

Open in PubMed

Identifiers

PMID: 41537529
DOI: 10.55563/clinexprheumatol/820f4x

Genes

CMAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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