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Article

FGF10/IGSF3 Variants in Bony Congenital Nasolacrimal Duct Obstruction: A Genotype-Phenotype Study of Syndromic Versus Isolated Disease.

Investigative ophthalmology & visual science - 1 Dec 2025

Li Yuchen, Feng Zhao Xun, Cui Yanhui, Sun Jihang, Liu Wen, Xiao Xuefeng, Quan Xiaojie, Zhang Chengyue, Li Li

Abstract excerpt

Purpose: The purpose of this study was to identify pathogenic variants associated with congenital bony nasolacrimal duct obstruction (bony CNLDO) and to clarify genotype-phenotype correlations. Methods: In this single-center retrospective case study, children with clinically confirmed bony CNLDO and their relatives underwent detailed ophthalmic, systemic examinations, orbital computed tomography (CT), and...

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Identifiers

PMID: 41533940
DOI: 10.1167/iovs.66.15.69
PMCID: PMC12743491

Genes

FGF10
IGSF3

Variants

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