Genetic and metabolic regulation of eggshell quality in aging hens: Integrated multi-omics insights into CYP7A1, CALM1, and cholic/stearic acid metabolism.

Abstract excerpt

While breeding improvements have prolonged the laying cycle for greater productivity, a concurrent deterioration in eggshell quality is commonly observed in aged hens. To investigate the genetic basis of this deterioration, we conducted the multi-omics analyses on the hypothalamus, liver, duodenum, and uterus from 100-week-old Rhode Island Red hens. We identified significant genomic regions associated with total...

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• Aging
• Chickens
• Egg Shell
• Gene Expression Profiling
• Gene Expression Regulation