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Article

Homomorphic encryption enables privacy preserving polygenic risk scores.

Cell reports methods - 26 Jan 2026

Knight Elizabeth, Li Jiaqi, Jensen Matthew, Yolou Israel, Kockan Can, Gerstein Mark

Abstract excerpt

Polygenic risk score models (PRSs) are important tools in precision medicine, enabling personalized risk prediction; however, they raise privacy concerns. Fully homomorphic encryption (FHE) provides a potential solution, allowing computation on encrypted genomic data. Here, we develop an open-source implementation of FHE for PRS (HEPRS), available online. HEPRS involves a three party system: clients (clinicians...

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Share to Genetic Risk Score
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41512862
DOI: 10.1016/j.crmeth.2025.101271
PMCID: PMC12853174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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