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Intrinsic capacity-frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study.

Experimental gerontology - 1 Feb 2026

Cacciatore Stefano, Calvani Riccardo, Prokopidis Konstantinos, Schlögl Mathias, Russo Andrea, Tosato Matteo, Anton Stephen D, Leeuwenburgh Christiaan, Batsis John A, Marzetti Emanuele, Landi Francesco

Abstract excerpt

BACKGROUND: Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC-frailty phenotypes and systemic inflammation in...

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PMID: 41506300
DOI: 10.1016/j.exger.2026.113026

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