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The Recurring Issue of Syphilis in Europe: Comment on "Ancient Genomes Reveal a Deep History of Treponema pallidum in the Americas".

The Journal of infectious diseases - 16 Jun 2026

Dehmane M, Drancourt M, Hama H Oumarou

Abstract excerpt

Syphilis is a sexually transmitted infection caused by Treponema pallidum, whose origin in Europe remains debated. Recent analysis of 5 ancient T. pallidum genomes from Central America surrounding Columbus's time revealed genetic diversity suggesting an emergence of syphilis in Europe after the 16th-century colonization of the Americas. However, this study missed 2 pre-Columbian Mexican genomes and...

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PMID: 41502134
DOI: 10.1093/infdis/jiag022

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