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Article

ARR3 variant-induced cone mosaicism alters cone subtype composition and disrupts phototransduction.

Zoological research - 18 Jan 2026

Ouyang Jiamin, Yi Zhen, Jiang Yi, Li Xueqing, Wang Gongpei, Wang Yingwei, Du Wenting, Chen Shuowei, Dong Yijun, Xiao Xueshan, Hejtmancik J Fielding, Sun Wenmin, Zhang Qingjiong

Abstract excerpt

Heterozygous variants in ARR3, encoding cone arrestin, have emerged as a frequent cause of early-onset high myopia with a unique X-linked female-limited inheritance pattern. However, the mechanistic basis for this unusual anti-X-linked pattern is still unclear. Developmental expression profiling in mice demonstrated robust Arr3 expression in the retina from postnatal day 14 onward, with localization confined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41493082
DOI: 10.24272/j.issn.2095-8137.2025.103
PMCID: PMC13276656

Genes

ARR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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