Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genome-wide association and transcriptome studies identify candidate genes regulating perirenal fat deposition in sheep.

Genomics - 1 Jan 2026

Fu Xiaoyu, Zhao Liming, Tian Huibin, Zhang Deyin, Zhang Yukun, Zhao Yuan, Cheng Jiangbo, Li Xiaolong, Xu Quanzhong, Xu Dan, Yang Xiaobin, Ma Zongwu, Wu Weiwei, Li Fadi, Wang Weimin, Zhang Xiaoxue

Abstract excerpt

Perirenal fat deposition significantly impacts sheep carcass quality and economic efficiency. To elucidate the underlying genetic regulation, we performed a genome-wide association study (GWAS) on 556 Hu sheep and a comparative transcriptome analysis on 24 Hu sheep (12 with high- and 12 with low-perirenal fat deposition), all with accurate phenotypic records. Furthermore, hub genes and tissue-specific genes...

Topics

Animals
Sheep
Genome-Wide Association Study
Transcriptome
Lipid Metabolism
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41453584
DOI: 10.1016/j.ygeno.2025.111182

Genes

DNAH17
TIMP2
LPL
SOCS3
THRSP
ACACA
ACSS2
ADRB3
APOE
BSCL2
DGAT1
GOT1
KIF5B
LEP
PLIN5
PNPLA2
SAR1B
SETD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association and transcriptome studies identify candidate genes regulating perirenal fat deposition in sheep.PMID 41453584Read ↗

RNA-Seq based genetic variant discovery provides new insights into controlling fat deposition in the tail of sheep.Semantic proximity Read ↗

Transcriptome Analysis of Adipose Tissues from Five Sheep Breeds Reveals Key Genes Involved in Fat Deposition.Semantic proximity Read ↗

Comparative transcriptome analysis reveals potentially novel roles of Homeobox genes in adipose deposition in fat-tailed sheep.Semantic proximity Read ↗

Multi-omics integrated analysis reveals the molecular mechanism of tail fat deposition differences in sheep with different tail typesSemantic proximity Read ↗

Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep.Semantic proximity Read ↗

Transcriptome profile analysis of adipose tissues from fat and short-tailed sheep.Semantic proximity Read ↗

Genome-wide association study and pathway analysis for fat deposition traits in nellore cattle raised in pasture-based systems.Semantic proximity Read ↗

Fat-tail allele-specific expression genes may affect fat deposition in tail of sheep.Semantic proximity Read ↗

Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries).Semantic proximity Read ↗

Genome-wide association studies of preweaning growth and in vivo carcass composition traits in Esme sheep.Semantic proximity Read ↗

Fine mapping of candidate regions associated with fat deposition in thin and fat tail sheep breeds suggests new insights into molecular aspects of fat tail selectionSemantic proximity Read ↗

GLIS1, a potential candidate gene affect fat deposition in sheep tail.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.