Comparative genomic and phenotypic analysis of Escherichia coli ST1193 and ST131 from urinary and bloodstream infections: insights into resistance, virulence, and divergent strategies.

Abstract excerpt

BACKGROUND: The global dissemination of multidrug-resistant (MDR) Escherichia coli (E. coli) clones, particularly the pandemic ST131 and the emerging ST1193, poses a serious public health threat. While ST131 is well-studied, the factors enabling ST1193’s rapid dissemination across both urinary and bloodstream infection niches remain unclear. METHODS: We compared 48 urinary (UPEC) and bloodstream (BPEC) E. coli...

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