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Host-adapted probiotic potential of Ligilactobacillus agilis 2-2 revealed by comparative genomic and phenotypic analyses.

Poultry science - 1 Feb 2026

Zhang Zhen, Lv Yang, Guo Zisheng, Liu Lei, Chen Xiaohui, Han Wenjing, Wei Jinshuo, Guo Songtao, Sun Yanmei, Wang Shiwei

Abstract excerpt

Host-specific adaptation shapes the evolution of safe and effective probiotics. In this study, we performed the first pan-genome analysis of Ligilactobacillus agilis using 40 genomes from poultry and mammalian sources. The species exhibits an open, highly plastic genome with host-driven divergence in carbohydrate metabolism. Glycosyltransferase GT2, bglF_2 and tcyB/C were enriched in mammalian strains, whereas...

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Identifiers

PMID: 41418533
DOI: 10.1016/j.psj.2025.106274
PMCID: PMC12774754

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