Polygenic risk for autism spectrum disorder based on four group comparison across term and preterm birth.

Abstract excerpt

Preterm birth increases the risk of adverse neurodevelopmental outcomes, including autism spectrum disorder (ASD). Separately, polygenic risk scores (PRS) evaluate genetic liability to ASD. While both elevated PRS and preterm birth contribute to ASD risk, the extent to which gestational age interacts with genetic liability is unknown. We analyzed ASD PRS in 2387 individuals from the Center for Applied Genomics...

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