Article
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
Gut microbes - 31 Dec 2025
Adriouch Solia, Belda Eugeni, Swartz Timothy D, Forslund Sofia, Prifti Edi, Aron-Wisnewsky Judith, Chakaroun Rima, Nielsen Trine, Poitou Christine, Bel-Lassen Pierre, Rouault Christine, Le Roy Tiphaine, Andrikopoulos Petros, Chechi Kanta, Puig-Castellví Francesc, Dionicio Inés Castro, Froguel Philippe, Holmes Bridget, Alili Rohia, Andreelli Fabrizio, Soula Hedi, Salem Joe-Elie, Falony Gwen, Vieira-Silva Sara, Raes Jeroen, Bork Peer, Stumvoll Michael, Pedersen Oluf, Ehrlich S Dusko, Dumas Marc-Emmanuel, Oppert Jean-Michel, Dao Maria Carlota, Zucker Jean-Daniel, Clément Karine
Abstract excerpt
Lifestyle factors influence both gut microbiome composition and host metabolism, yet their combined and mediating effects on host phenotypes remain poorly characterized in cardiometabolic populations. In 1,643 participants from the MetaCardis study, we developed a composite lifestyle score (QASD: dietary quality, physical activity, smoking, and diet diversity) that outperformed individual lifestyle variables in...
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