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Sleep patterns, genetic factors and the risk of cirrhosis: a prospective cohort study.

Human genomics - 15 Dec 2025

Lin Fei, Zhang Haoyu, Xu Hongwei, Cheng Luying, Guo Wen, Wang Mengying, Yu Chengxiao

Abstract excerpt

BACKGROUND: Recent studies have shown that unhealthy sleep behaviors are associated with chronic liver disease. However, the association of sleep patterns and genetic susceptibility with the incidence of cirrhosis remains inadequately elucidated. METHODS: This study included 364,308 participants initially free of liver cirrhosis from the UK Biobank. Sleep patterns were derived based on five self-reported sleep...

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PMID: 41398300
DOI: 10.1186/s40246-025-00872-0
PMCID: PMC12821875

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