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Whole-genome sequencing-based typing methods for Clostridium butyricum strains from clinical, animal, plant, and environmental sources.

Microbiology spectrum - 3 Feb 2026

Cassir Nadim, Mesa Victoria, Ferraris Laurent, Delannoy Johanne, Mikrat Yousra, Adjamian Anthony, Diancourt Laure, Mazuet Christelle, Barbut Frédéric, La Scola Bernard, Aires Julio

Abstract excerpt

Clostridium butyricum exhibits a dual role, acting not only as a probiotic but also as an opportunistic pathogen associated with neonatal necrotizing enterocolitis (NEC) and infant botulism. We aimed to establish high-resolution genotyping frameworks to improve molecular surveillance and outbreak investigations. We analyzed 297 C. butyricum genomes, including 200 isolates from preterm neonates across 13 French...

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Identifiers

PMID: 41384747
DOI: 10.1128/spectrum.02619-25
PMCID: PMC12889113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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