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Article

Genotype-based comparison of bone microstructure in adult patients with classical osteogenesis imperfecta.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Jan 2026

Bartosik Mikolaj, Prengel Mascha, Delsmann Julian, Oswald Julia, Kornak Uwe, Barvencik Florian, Schinke Thorsten, Amling Michael, Oheim Ralf

Abstract excerpt

In 115 adult patients with classical OI, reduced bone structure was observed in patients with COL1A1 variants compared to those with COL1A2 variants. In addition, bone structure in the distal radius was differentially affected in individuals with quantitative COL1A1/2 variants in comparison to patients carrying qualitative variants. PURPOSE: Classical osteogenesis imperfecta (OI) is genetically determined by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41364339
DOI: 10.1007/s00198-025-07774-w
PMCID: PMC12847233

Genes

COL1A1
COL1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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