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Article

Subphenotyping aneurysmal subarachnoid Hemorrhage using clinical and biological data clustering.

Journal of critical care - 1 Apr 2026

Santafé Manel, Quintana Manuel, Sánchez Anna, Gràcia Rosa-Maria, Campos-Fernandez Daniel, Abraira Laura, Santamarina Estevo

Abstract excerpt

BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is an heterogeneous disease with variable outcomes, even among patients with similar clinical and radiological severity. Additional research is needed to better stratify aSAH patients. OBJECTIVES: To identify distinct clinical subphenotypes of aSAH, we applied clustering analysis using clinical, radiological, and laboratory data. METHODS: We conducted a...

Read the complete abstract on PubMed

Topics

Humans
Subarachnoid Hemorrhage
Male
Female
Middle Aged
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Cluster Analysis

Aged

S100 Calcium Binding Protein beta Subunit

Phenotype

HMGB1 Protein

Toll-Like Receptor 4

Intensive Care Units

Adult

Source

Identifiers

PMID: 41317655
DOI: 10.1016/j.jcrc.2025.155365

Genes

S100B
HMGB1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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