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Low neutrophil-to-lymphocyte ratio identifies secondary polycythemia in patients with erythrocytosis.

Scientific reports - 26 Nov 2025

Yoon Seug Yun, Kwon Seong Soon, Jeong Sun Young, Lee Min-Young, Kim Kyoung Ha, Kim Se Hyung, Bae Sang Byung, Lee Namsu, Park Sung Kyu, Won Jong-Ho

Abstract excerpt

The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, may assist in differentiating polycythemia vera (PV) from secondary polycythemia (SP), especially when access to JAK2 mutation testing is limited due to cost or delayed turnaround. We retrospectively analyzed 655 patients with erythrocytosis who underwent JAK2 mutation testing between 2007 and 2024 across three South Korean...

Topics

Humans
Polycythemia
Female
Janus Kinase 2
Neutrophils
Lymphocytes
Retrospective Studies
Polycythemia Vera
Male
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Erythropoietin

Mutation

ROC Curve

Biomarkers

Source

Open in PubMed Open full text

Identifiers

PMID: 41298565
DOI: 10.1038/s41598-025-26200-z
PMCID: PMC12657909

Genes

JAK2
EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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