Article
Arabidopsis homologs of gp78 modulate the HRD1 complex component AtOS9 by ERAD tuning.
Journal of integrative plant biology - 1 Feb 2026
Liu Ruijun, Zhao Kangxu, Ge Fengyong, Chen Qian, Zhao Qingzhen, Wang Qian, Li Yaqiong, Yu Feifei, Xia Ran, Xie Qi, Wu Yaorong
Abstract excerpt
Endoplasmic reticulum-associated degradation (ERAD) is an important mechanism for degrading misfolded proteins, and is mediated by different complexes containing several conserved ER-localized ubiquitin ligases, such as Hrd1, Doa10, and gp78. Recent studies have shown that the ERAD machinery is conserved in eukaryotes. However, it remains unknown whether plants have gp78 homologs. We report a functional study of...
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