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Article

Phenotypic and functional characterisation of liver-infiltrating T-cells in a case of CFTR modulator induced drug-induced liver injury.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2026

Clarke Elsie, Gardner Joshua, Howsawi Alanood, Gillgrass Lindsey, Roehmel Jobst F, Whitaker Paul, Tachtatzis Phaedra, Cratchley Alyn, Peckham Daniel, Naisbitt Dean J

Abstract excerpt

BACKGROUND: The introduction of CFTR modulators has been transformative for many people with cystic fibrosis (CF). The drugs are generally well tolerated although adverse reactions such as delayed-type T-cell mediated hypersensitivity and drug-induced liver injury (DILI) have been reported. Here, we characterise a novel underlying immunological mechanism driving DILI post Elexacaftor/Tezacaftor/Ivacaftor (ETI)...

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Identifiers

PMID: 41274791
DOI: 10.1016/j.jcf.2025.11.011

Genes

CFTR
CXCR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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